Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development
Identifieur interne : 005947 ( Main/Exploration ); précédent : 005946; suivant : 005948Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development
Auteurs : Fu-Jung Lin [États-Unis] ; Xinpu Chen [États-Unis] ; Jun Qin [États-Unis] ; Young-Kwon Hong [États-Unis] ; Ming-Jer Tsai [États-Unis] ; Sophia Y. Tsai [États-Unis]Source :
- The Journal of Clinical Investigation [ 0021-9738 ] ; 2010.
Descripteurs français
- KwdFr :
- Animaux, Facteur de croissance endothéliale vasculaire de type C (métabolisme), Facteur de transcription COUP-TFII (métabolisme), Femelle, Homozygote, Lymphangiogenèse, Mouvement cellulaire, Mâle, Métastase tumorale, Neuropiline 2 (biosynthèse), Neuropiline 2 (génétique), Petit ARN interférent (métabolisme), Prolifération cellulaire, Régulation de l'expression des gènes au cours du développement, Sites de fixation, Souris, Souris de lignée C57BL.
- MESH :
- biosynthèse : Neuropiline 2.
- génétique : Neuropiline 2.
- métabolisme : Facteur de croissance endothéliale vasculaire de type C, Facteur de transcription COUP-TFII, Petit ARN interférent.
- Animaux, Femelle, Homozygote, Lymphangiogenèse, Mouvement cellulaire, Mâle, Métastase tumorale, Prolifération cellulaire, Régulation de l'expression des gènes au cours du développement, Sites de fixation, Souris, Souris de lignée C57BL.
English descriptors
- KwdEn :
- Animals, Binding Sites, COUP Transcription Factor II (metabolism), Cell Movement, Cell Proliferation, Female, Gene Expression Regulation, Developmental, Homozygote, Lymphangiogenesis, Male, Mice, Mice, Inbred C57BL, Neoplasm Metastasis, Neuropilin-2 (biosynthesis), Neuropilin-2 (genetics), RNA, Small Interfering (metabolism), Vascular Endothelial Growth Factor C (metabolism).
- MESH :
- chemical , biosynthesis : Neuropilin-2.
- chemical , genetics : Neuropilin-2.
- chemical , metabolism : COUP Transcription Factor II, RNA, Small Interfering, Vascular Endothelial Growth Factor C.
- Animals, Binding Sites, Cell Movement, Cell Proliferation, Female, Gene Expression Regulation, Developmental, Homozygote, Lymphangiogenesis, Male, Mice, Mice, Inbred C57BL, Neoplasm Metastasis.
Abstract
The lymphatic system plays a key role in tissue fluid homeostasis. Lymphatic dysfunction contributes to the pathogenesis of many human diseases, including lymphedema and tumor metastasis. However, the mechanisms regulating lymphangiogenesis remain largely unknown. Here, we show that COUP-TFII (also known as Nr2f2), an orphan member of the nuclear receptor superfamily, mediates both developmental and pathological lymphangiogenesis in mice. Conditional ablation of
Url:
DOI: 10.1172/JCI40101
PubMed: 20364082
PubMed Central: 2860940
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002F31
- to stream Pmc, to step Curation: 002F30
- to stream Pmc, to step Checkpoint: 003452
- to stream PubMed, to step Corpus: 002B15
- to stream PubMed, to step Curation: 002B15
- to stream PubMed, to step Checkpoint: 002B15
- to stream Ncbi, to step Merge: 003A35
- to stream Ncbi, to step Curation: 003A35
- to stream Ncbi, to step Checkpoint: 003A35
- to stream Main, to step Merge: 005999
- to stream Main, to step Curation: 005947
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development</title><author><name sortKey="Lin, Fu Jung" sort="Lin, Fu Jung" uniqKey="Lin F" first="Fu-Jung" last="Lin">Fu-Jung Lin</name><affiliation wicri:level="2"><nlm:aff id="JCI40101">Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Chen, Xinpu" sort="Chen, Xinpu" uniqKey="Chen X" first="Xinpu" last="Chen">Xinpu Chen</name><affiliation wicri:level="2"><nlm:aff id="JCI40101">Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Qin, Jun" sort="Qin, Jun" uniqKey="Qin J" first="Jun" last="Qin">Jun Qin</name><affiliation wicri:level="2"><nlm:aff id="JCI40101">Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Hong, Young Kwon" sort="Hong, Young Kwon" uniqKey="Hong Y" first="Young-Kwon" last="Hong">Young-Kwon Hong</name><affiliation wicri:level="4"><nlm:aff id="JCI40101">Department of Surgery and Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Surgery and Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Tsai, Ming Jer" sort="Tsai, Ming Jer" uniqKey="Tsai M" first="Ming-Jer" last="Tsai">Ming-Jer Tsai</name><affiliation wicri:level="2"><nlm:aff id="JCI40101">Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="JCI40101">Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Program in Developmental Biology, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Tsai, Sophia Y" sort="Tsai, Sophia Y" uniqKey="Tsai S" first="Sophia Y." last="Tsai">Sophia Y. Tsai</name><affiliation wicri:level="2"><nlm:aff id="JCI40101">Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20364082</idno><idno type="pmc">2860940</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860940</idno><idno type="RBID">PMC:2860940</idno><idno type="doi">10.1172/JCI40101</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">002F31</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002F31</idno><idno type="wicri:Area/Pmc/Curation">002F30</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002F30</idno><idno type="wicri:Area/Pmc/Checkpoint">003452</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003452</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002B15</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002B15</idno><idno type="wicri:Area/PubMed/Curation">002B15</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002B15</idno><idno type="wicri:Area/PubMed/Checkpoint">002B15</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002B15</idno><idno type="wicri:Area/Ncbi/Merge">003A35</idno><idno type="wicri:Area/Ncbi/Curation">003A35</idno><idno type="wicri:Area/Ncbi/Checkpoint">003A35</idno><idno type="wicri:doubleKey">0021-9738:2010:Lin F:direct:transcriptional:regulation</idno><idno type="wicri:Area/Main/Merge">005999</idno><idno type="wicri:Area/Main/Curation">005947</idno><idno type="wicri:Area/Main/Exploration">005947</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development</title><author><name sortKey="Lin, Fu Jung" sort="Lin, Fu Jung" uniqKey="Lin F" first="Fu-Jung" last="Lin">Fu-Jung Lin</name><affiliation wicri:level="2"><nlm:aff id="JCI40101">Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Chen, Xinpu" sort="Chen, Xinpu" uniqKey="Chen X" first="Xinpu" last="Chen">Xinpu Chen</name><affiliation wicri:level="2"><nlm:aff id="JCI40101">Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Qin, Jun" sort="Qin, Jun" uniqKey="Qin J" first="Jun" last="Qin">Jun Qin</name><affiliation wicri:level="2"><nlm:aff id="JCI40101">Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Hong, Young Kwon" sort="Hong, Young Kwon" uniqKey="Hong Y" first="Young-Kwon" last="Hong">Young-Kwon Hong</name><affiliation wicri:level="4"><nlm:aff id="JCI40101">Department of Surgery and Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Surgery and Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Tsai, Ming Jer" sort="Tsai, Ming Jer" uniqKey="Tsai M" first="Ming-Jer" last="Tsai">Ming-Jer Tsai</name><affiliation wicri:level="2"><nlm:aff id="JCI40101">Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="JCI40101">Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Program in Developmental Biology, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Tsai, Sophia Y" sort="Tsai, Sophia Y" uniqKey="Tsai S" first="Sophia Y." last="Tsai">Sophia Y. Tsai</name><affiliation wicri:level="2"><nlm:aff id="JCI40101">Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Clinical Investigation</title><idno type="ISSN">0021-9738</idno><idno type="eISSN">1558-8238</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Binding Sites</term><term>COUP Transcription Factor II (metabolism)</term><term>Cell Movement</term><term>Cell Proliferation</term><term>Female</term><term>Gene Expression Regulation, Developmental</term><term>Homozygote</term><term>Lymphangiogenesis</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Neoplasm Metastasis</term><term>Neuropilin-2 (biosynthesis)</term><term>Neuropilin-2 (genetics)</term><term>RNA, Small Interfering (metabolism)</term><term>Vascular Endothelial Growth Factor C (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Facteur de croissance endothéliale vasculaire de type C (métabolisme)</term><term>Facteur de transcription COUP-TFII (métabolisme)</term><term>Femelle</term><term>Homozygote</term><term>Lymphangiogenèse</term><term>Mouvement cellulaire</term><term>Mâle</term><term>Métastase tumorale</term><term>Neuropiline 2 (biosynthèse)</term><term>Neuropiline 2 (génétique)</term><term>Petit ARN interférent (métabolisme)</term><term>Prolifération cellulaire</term><term>Régulation de l'expression des gènes au cours du développement</term><term>Sites de fixation</term><term>Souris</term><term>Souris de lignée C57BL</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Neuropilin-2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Neuropilin-2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>COUP Transcription Factor II</term><term>RNA, Small Interfering</term><term>Vascular Endothelial Growth Factor C</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Neuropiline 2</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Neuropiline 2</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type C</term><term>Facteur de transcription COUP-TFII</term><term>Petit ARN interférent</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Binding Sites</term><term>Cell Movement</term><term>Cell Proliferation</term><term>Female</term><term>Gene Expression Regulation, Developmental</term><term>Homozygote</term><term>Lymphangiogenesis</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Neoplasm Metastasis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Homozygote</term><term>Lymphangiogenèse</term><term>Mouvement cellulaire</term><term>Mâle</term><term>Métastase tumorale</term><term>Prolifération cellulaire</term><term>Régulation de l'expression des gènes au cours du développement</term><term>Sites de fixation</term><term>Souris</term><term>Souris de lignée C57BL</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The lymphatic system plays a key role in tissue fluid homeostasis. Lymphatic dysfunction contributes to the pathogenesis of many human diseases, including lymphedema and tumor metastasis. However, the mechanisms regulating lymphangiogenesis remain largely unknown. Here, we show that COUP-TFII (also known as Nr2f2), an orphan member of the nuclear receptor superfamily, mediates both developmental and pathological lymphangiogenesis in mice. Conditional ablation of <italic>COUP-TFII</italic> at an early embryonic stage resulted in failed formation of pre-lymphatic ECs (pre-LECs) and lymphatic vessels. <italic>COUP-TFII</italic> deficiency at a late developmental stage resulted in loss of LEC identity, gain of blood EC fate, and impaired lymphatic vessel sprouting. siRNA-mediated downregulation of <italic>COUP-TFII</italic> in cultured primary human LECs demonstrated that the maintenance of lymphatic identity and VEGF-C–induced lymphangiogenic activity, including cell proliferation and migration, are COUP-TFII–dependent and cell-autonomous processes. COUP-TFII enhanced the pro-lymphangiogenic actions of VEGF-C, at least in part by directly stimulating expression of neuropilin-2, a coreceptor for VEGF-C. In addition, <italic>COUP-TFII</italic> inactivation in a mammary gland mouse tumor model resulted in inhibition of tumor lymphangiogenesis, suggesting that COUP-TFII also regulates neo-lymphangiogenesis in the adult. Thus, COUP-TFII is a critical factor that controls lymphangiogenesis in embryonic development and tumorigenesis in adults.
</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Texas</li></region><settlement><li>Los Angeles</li></settlement><orgName><li>Université de Californie du Sud</li></orgName></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Lin, Fu Jung" sort="Lin, Fu Jung" uniqKey="Lin F" first="Fu-Jung" last="Lin">Fu-Jung Lin</name></region><name sortKey="Chen, Xinpu" sort="Chen, Xinpu" uniqKey="Chen X" first="Xinpu" last="Chen">Xinpu Chen</name><name sortKey="Hong, Young Kwon" sort="Hong, Young Kwon" uniqKey="Hong Y" first="Young-Kwon" last="Hong">Young-Kwon Hong</name><name sortKey="Qin, Jun" sort="Qin, Jun" uniqKey="Qin J" first="Jun" last="Qin">Jun Qin</name><name sortKey="Tsai, Ming Jer" sort="Tsai, Ming Jer" uniqKey="Tsai M" first="Ming-Jer" last="Tsai">Ming-Jer Tsai</name><name sortKey="Tsai, Ming Jer" sort="Tsai, Ming Jer" uniqKey="Tsai M" first="Ming-Jer" last="Tsai">Ming-Jer Tsai</name><name sortKey="Tsai, Sophia Y" sort="Tsai, Sophia Y" uniqKey="Tsai S" first="Sophia Y." last="Tsai">Sophia Y. Tsai</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005947 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 005947 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:2860940
|texte= Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:20364082" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |